![]() Bortezomib (Velcade) is a proteasome inhibitor known to suppress activation of these TLRs. Thus, therapeutic applications of antagonists of these TLRs for such disorders are being investigated. 10 Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan and Research and Development Center for Immunology, China Medical University, Taichung 40402, Taiwan of TLR7-9 has been linked to the pathogenesis of autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. ![]() 10 Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan and Research and Development Center for Immunology, China Medical University, Taichung 40402, Taiwan 1 Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan.9 School of Medicine, University of Nankai, Tianjin 300071, China. ![]()
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